If you develop back pain from taking Trelegy Ellipta, talk with your doctor. Serious side effects and their symptoms can include: Note: Long-acting beta2-agonists (LABAs) are known to increase the risk of asthma-related death and hospitalization if theyre taken alone. This means that after 3-4 hours, there will only be approximately of the medication in your system as compared to the peak of the medication. Taking too much umeclidinium isnt likely to cause you any serious side effects. According to GoodRx, if you are in the post-deductible phase, your copay could range between $0-$713. We comply with the HONcode standard for trustworthy health information. Off-label use is when a drug thats approved to treat one condition is used to treat a different condition. Brand-name medications usually cost more than generics. Here are answers to some frequently asked questions about Trelegy Ellipta. 2018;378(18):1671-1680. Step 1: Prepare a dose Wait to open the cover until you are ready to take your dose. However, its possible that alcohol may worsen chronic obstructive pulmonary disease (COPD) or asthma symptoms, which Trelegy Ellipta is used to treat. Trelegy Ellipta and Symbicort are both approved to treat COPD and asthma in adults. These lists dont include all possible side effects. Trelegy Ellipta is NOT used as a fast-acting rescue inhaler for sudden breathing problems. If you have headaches that are bothersome to you during your Trelegy Ellipta treatment, talk with your doctor. Your doctor or pharmacist can help you take your first dose or show you the proper technique. 4. Trelegy Ellipta is also contraindicated in people with allergies to any of the ingredients in the medication, including fluticasone furoate, umeclidinium, vilanterol, lactose monohydrate, and magnesium stearate. Tell them about all prescription, over-the-counter, and other drugs you take. Weight gain isnt a side effect thats been reported with Trelegy Ellipta use. Using Trelegy Ellipta for a long time can raise eye pressure, worsen glaucoma, and cause cataracts (cloudiness in the eyes). This helps prevent others, including children and pets, from taking the drug by accident. With NiceRx, you'll only pay $49 to obtain your Trelegy Ellipta, regardless of the retail price. Trelegy Ellipta is made of three medications that work to help ease the symptoms of COPD. In comparison, back pain only occurred in about 1% to 4%* of people who took only fluticasone and vilanterol (two of the three ingredients in Trelegy Ellipta). Rates of pneumonia were higher in patients receiving Trelegy triple therapy (8%) compared to Anoro (5%) or Breo (7%) in a 52-week study. Best food forward: Are algae the future of sustainable nutrition? However, babies whose mothers were given vilanterol while pregnant did have birth defects affecting their bones. Symbicort is also approved to treat asthma in children ages 6 years and older. Some may be a better fit for you than others. The drugs are fluticasone, umeclidinium, and vilanterol. If you take umeclidinium with another anticholinergic medication, the drugs effects can combine and increase your risk for side effects. Do not use Trelegy Ellipta to treat sudden, severe symptoms of COPD or asthma. You should always consult your doctor or other healthcare professional before taking any medication. Certain antidepressant medications can interact with Trelegy Ellipta. If youre having sudden trouble breathing, your doctor will likely want you to use a rescue inhaler such as albuterol (Ventolin HFA, ProAir) or levalbuterol (Xopenex). "Trelegy" is the name of the medication inside the inhaler. Last updated on Oct 11, 2022. Call your doctor for medical advice about side effects, precautions or warnings. You can find an updated list of ingredients at the end of the manufacturers patient information. constipation. Trelegy Ellipta contains umeclidinium, which is a type of drug called an anticholinergic. If you have sudden trouble breathing, your doctor will likely want you to use a rescue inhaler such as albuterol (Ventolin HFA, ProAir) or levalbuterol (Xopenex). Only remove the inhaler from the unopened tray when ready to use. It works by activating adenyl cyclase, which then catalyzes a reaction from adenosine triphosphate (ATP) to cyclic 3,5,adenosine monophosphate (cyclic AMP). Do not use this medicine if you are allergic to any active ingredients (fluticasone furoate, umeclidinium, vilanterol) or inactive ingredients (lactose monohydrate [contains milk proteins], magnesium stearate). Keep the inhaler dry and away from heat and sunlight. Accessed Oct. 21, 2020 at https://www.gsksource.com/pharma/content/dam/GlaxoSmithKline/US/en/Prescribing_Information/Trelegy/pdf/TRELEGY-ELLIPTA-PI-PIL-IFU.PDF, FDA Approves Trelegy Ellipta (fluticasone furoate/umeclidinium/vilanterol) for the Treatment of Asthma. This means that your doctor and insurance company will need to communicate about your prescription before the insurance company will cover the drug. All rights reserved. In studies, Trelegy has shown a positive effect on breathing tests (FEV1) with the first dose, but it may take several weeks or longer for your overall symptoms to improve in COPD or asthma. More recently, in 2020, the drug was approved to treat asthma. However, be sure to take the dosage your doctor prescribes for you. Do NOT take two doses at the same time. We're talking about chronic bronchitis and emphysema. Trelegy Ellipta is an option for the treatment of asthma in patients not controlled on inhaled corticosteroids and long-acting beta agonists alone. Fluticasone furoate is an inhaled corticosteroid that works by decreasing inflammation, which is a main component of COPD and asthma symptoms. If youre taking a beta-blocker, tell your doctor before you start using Trelegy Ellipta. They can recommend medication to treat the current infection. Keep all medications away from children and pets. The FDA-approved strength for treatment of both COPD and asthma in adults is fluticasone furoate 100 mcg / umeclidinium 62.5 mcg / vilanterol 25mcg. Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use Trelegy Ellipta only for the indication prescribed. Trelegy Ellipta is approved for long-term treatment of chronic obstructive pulmonary disease (COPD) and asthma. This drug comes with several precautions. How long does Trulicity stay in your system? COPD is a long-term disease in which the airways and air sacs inside the lungs become damaged or blocked, leading to difficulty breathing. And youll usually keep coughing up mucus. Trelegy Ellipta is not a rescue medicine for bronchospasm attacks and sudden breathing problems. Trelegy Ellipta contains lactose as a major excipient. Instead, youll use a rescue inhaler for sudden trouble breathing. However, other people dont feel or taste the medication, even if they use the inhaler properly. Dont take more than one dose in 24 hours. The word Ellipta refers to the specific type of dry powder inhaler that contains the drug. Saliva tests can detect cannabis for approximately 24 hours after use. Trelegy Ellipta has been evaluated in the treatment of asthma or COPD in studies ranging from 12- to 52-weeks long. One study showed that FEV1 in people who took Trelegy Ellipta was 59 mL higher than it was in people who took fluticasone and vilanterol. Improvements in lung function have also been seen when Trelegy was compared to Symbicort Turbuhaler in 24-week studies or with Symbicort plus Spiriva in 12 week studies. unpleasant or unusual taste in your mouth. However, beta-blockers can block the effects of Trelegy Ellipta and cause the medication to not work properly. (A generic drug is an exact copy of the active drug in a brand-name medication.). These drugs havent been directly compared in clinical studies. The medication is in a powder form that you breathe into your lungs. Do not take more than one inhalation per day in a 24-hour period. Its important that even if you dont feel or taste your dose, you dont take another dose. Its half-life is 11 hours. Call 911 if your symptoms feel life threatening or if you think youre having a medical emergency. These inhalers are easy to use and include a dose counter so that you know when to refill your prescription. If you miss your dose of Trelegy, take it as soon as you remember. Below are examples of these side effects. The word Ellipta refers to the specific type of inhaler that contains the drug. Rinse your mouth with water without swallowing after use to help prevent thrush (a yeast infection in your mouth and throat area). There may be another medication to treat your infection that wont interact with Trelegy Ellipta. This is an inhaler that dispenses the drug as a spray, which you breathe into your lungs. You should store your Trelegy Ellipta inhaler at room temperature between 68F and 77F (20C and 25C). You should take Trelegy Ellipta according to your doctors or healthcare providers instructions. It should be stored in the unopened foil tray until it is ready for use. Trelegy Ellipta is a combination medication thats used to treat asthma. Strong cytochrome P450 3A4 inhibitors, like ketoconazole, an antifungal medicine, Monoamine oxidase inhibitors, a class of antidepressants, Anticholinergics, for example, cold or allergy medicines (Benadryl and others), FDA Approves Trelegy Ellipta (fluticasone furoate/umeclidinium/vilanterol) for the Treatment of Asthma. Clinical studies with over 2,400 patients evaluated improvement in lung function as measured by the change from baseline in trough forced expiratory volume over one second (FEV1) at 24 weeks of treatment. GlaxoSmithKline. For information about this, see the Trelegy Ellipta use with other drugs section below. For information about this, see the Trelegy Ellipta use with other drugs section below. You may wonder how Trelegy Ellipta compares with other medications that are prescribed for similar uses. Its the first FDA-approved medication containing three active drugs that can be used once a day for either COPD or asthma. Subscribe to Drugs.com newsletters for the latest medication news, new drug approvals, alerts and updates. Use only your fast-acting inhalation medicine (for example, albuterol) for an attack. Youll take one inhalation (puff) of Trelegy Ellipta once a day. With emphysema, your lungs are damaged and have trouble passing air in and out. The actual price youll pay for either drug depends on your insurance plan, your location, and the pharmacy you use. Read and follow all patient instructions provided with the inhaler device. Strength. GlaxoSmithKline LLC, the manufacturer of Trelegy Ellipta, offers a coupon for the medication. To prevent yeast infection in your mouth, rinse with water (but do not swallow) after using Trelegy Ellipta. Note: Trelegy Ellipta is meant to be used over time to control COPD symptoms. To keep track of how long you have been using this medicine, write the date of when you open the tray on inhaler label. Medically reviewed by Leigh Ann Anderson, PharmD. umeclidinium, a long-acting muscarinic antagonist (LAMA), an anticholinergic bronchodilator that helps to block muscle tightening around your airways to improve breathing. your medical condition and treatment and ask if there is any new information about TRELEGY ELLIPTA. If youre breastfeeding, talk with your doctor before taking Trelegy Ellipta. These lists contain examples of mild side effects that can occur with Trelegy Ellipta, with Breo Ellipta, or with both drugs (when taken individually). Cmax was reached about 30 minutes to 1 hour post-dose. For patients who do not respond adequately to TRELEGY 200 once daily, re-evaluate and consider other therapeutic regimens and additional therapeutic options. If you have been using an oral steroid (corticosteroid) medication, you should not stop using it suddenly. Each inhaler has two foil strips inside it that contain blisters of the medication. It reaches steady state within 14 days of daily dosing. Trelegy Ellipta contains three active drug ingredients: fluticasone, vilanterol, and umeclidinium. It is the fast acting steroid and usually has a half-life around 2-3 days. The drug isnt meant to be used for sudden breathing problems caused by COPD. If you are between the ages of 18 and 60, take no other medication or have no other medical conditions, side effects you are more likely to experience include: This is not a complete list of side effects, precautions or warnings, and others may occur. Never take two doses at once to try to make up for a missed dose. Three active drug ingredients make up Trelegy Ellipta: fluticasone furoate, umeclidinium, and vilanterol. Researchers measured peoples forced expiratory volume in 1 second (FEV1), which is the amount of air you can force out of your lungs in 1 second. Can you just stop taking Trulicity? If you need a fast-acting inhaler like albuterol, contact your health care provider right away, as you should always have one on hand. Its important to note that Trelegy Ellipta contains a powder form of lactose (a sugar in milk). Call 911 if your symptoms feel life threatening or if you think youre having a medical emergency. Therefore, these medications can cause some very similar side effects. Trelegy Ellipta is good for only 6 weeks after opening it or until the counter reads 0, meaning that no doses are remaining. The studies showed that FEV1 in people who took Trelegy Ellipta was between 122 mL and 124 mL higher than it was in people who took fluticasone and vilanterol. An inactive ingredient is any part of the medication thats not the active ingredient.). You shouldnt take beta-blockers while youre using Trelegy Ellipta. This can cause an infection in your lungs and make it hard for you to breathe. Sherm 3 years ago. * This percentage range varied depending on the condition being treated and the dose of treatment given. Your monthly Trelegy Ellipta cost savings if eligible. This list does not contain all drugs that may interact with Trelegy Ellipta. fluticasone, an inhaled corticosteroid that lowers inflammation and swelling in the lung airways, vilanterol, a long-acting beta-agonist (LABA) bronchodilator that relaxes the airway muscles to help open airways. Accessed Oct. 4, 2022 at, Phase III CAPTAIN study of Trelegy Ellipta in patients with asthma meets primary endpoint. Trelegy Ellipta costs significantly more than Symbicort. In this trial, forced expiratory volume in 1 second (FEV1) was measured. Its not known if Trelegy Ellipta is safe to take during pregnancy. Lungs with COPD may be enlarged, have visible air pockets, or show other signs of damage in comparison to healthy lungs. It can improve symptoms of COPD for better breathing and to reduce the number of flare-ups (the worsening of your COPD symptoms). Steady state occurred within 6 days of daily dosing. GSK Press Release. When an ICS and LABA are used together, there is not a significant increased risk in hospitalizations and death from asthma problems. Trelegy Ellipta should be stored at room temperature between 68F and 77F (20C and 25C). If you do not have a fast-acting inhaler, call your doctor for a prescription. diarrhea. However, as mentioned above, weight gain wasnt a side effect of Trelegy Ellipta reported in clinical trials. Your doctor or pharmacist may also be able to recommend ways to help prevent a thrush infection from occurring in the future. If you miss a dose of Trelegy Ellipta, take it as soon as you remember, and then take your next dose at your usual time. Also tell them about any vitamins, herbs, and supplements you use. Trelegy is approved as a maintenance (long-term) medicine for use in either chronic obstructive pulmonary disease (COPD) or asthma in adults. And some of these side effects can become serious, such as overheating or hallucinating. So if you have a severe milk protein allergy, you may have an allergic reaction to this medication. Steady state occurs within 14 days of daily use. When you open the tray that contains Trelegy Ellipta, write the date that you opened it on the label of the inhaler. There have been reports of very serious allergic reactions in people with milk protein allergies who took other powder medications with lactose in them. Avoid storing this medication in areas where it could get damp or wet, such as in bathrooms, as it is a dry powder inhaler. With chronic bronchitis, you develop a cough that lasts a long time. Vilanterol, an ingredient in Trelegy Ellipta, is a LABA. COPD: TRELEGY 100/62.5/25 is for maintenance treatment of patients with chronic obstructive pulmonary disease (COPD). For more information about this, see the Trelegy Ellipta use with other drugs section below. Seek emergency medical treatment or call 911 if your breathing problems get worse quickly. Trelegy Ellipta and Symbicort are both brand-name drugs. COPD is a long-term lung disease that includes chronic bronchitis, emphysema, or both. In 2018, this use was expanded to include the daily maintenance treatment of airflow obstruction in patients with COPD. Your doctor will be able to determine if Trelegy Ellipta is safe for you to take with your specific eye problem. Trelegy Ellipta contains three active drug ingredients: fluticasone, vilanterol, and umeclidinium. Trelegy Ellipta is a once-daily therapy that combines three medicines into one inhaler. Instead, youll use a rescue inhaler for sudden trouble breathing. A significant improvement in trough FEV1 from baseline (the primary endpoint) was demonstrated at week 24 for Trelegy Ellipta. Its used to treat chronic obstructive pulmonary disease (COPD) and asthma. They may suggest other medications. The drug comes as an inhaler, Chronic obstructive pulmonary disease (COPD) is an umbrella term for conditions that cause airflow and breathing difficulties. Youll take one inhalation (puff) of the medication once a day. If you miss a dose of Trelegy Ellipta, take it as soon as you remember. Both treatment regimens were effective in controlling asthma exacerbations in 16% of people. Compared to Breo (fluticasone furoate / vilanterol) 100/25 mcg, Trelegy Ellipta 100/62.5/25 mcg once daily demonstrated a 110 mL significant improvement in FEV1 over a 24 week period. If you would like to report to the FDA a side effect youve had with Trelegy Ellipta, you can do so through MedWatch. Because it contains three medicines, it may be useful for those on a fixed-dose combination of fluticasone / vilanterol (Breo Ellipta) who need added bronchodilation, or those who are already using Breo Ellipta and Incruse Ellipta (umeclidinium) as 2 separate medicines. With asthma, you may have symptoms such as: Its important to note that Trelegy Ellipta is meant to be used over time to control asthma symptoms. Instead, youll use a rescue inhaler for sudden trouble breathing. Trelegy Ellipta is a combination medication. It is primarily metabolized via CYP3A4 and is also a substrate of P-glycoprotein transporter. This may help decrease your risk of getting oral thrush, which is a fungal infection in your mouth. Heres some information about the forms of each drug and how you take them. The current stance of the Food and Drug Administration (FDA) is to avoid using expired medications. We simply charge $49 a month per medication to cover the cost of our services. Alcohol may also weaken the activity of your immune system, making it easier for you to get an infection. Beta-blockers are common medications that help decrease blood pressure and steady your heart rhythm. They can tell you about other medications that may work well for you. Chronic Obstructive Pulmonary Disease (COPD): TRELEGY ELLIPTA 100 mcg/62.5 mcg/25 mcg is used in adults for the long-term treatment of a lung disease called Chronic Obstructive Pulmonary Disease or COPD. Hair testing is a reliable way to figure out long-term use of tobacco products and can be very accurate for as long as 1 to 3 months after you stop using tobacco. The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. If the drug does cause side effects, you may have: A vilanterol overdose may include serious symptoms, such as: Because these medications can affect the heart, your doctor will monitor your heart if you take too much Trelegy Ellipta. An interaction between two medications does not always mean that you must stop taking one of the medications; however, sometimes it does. Trelegy Ellipta is indicated for use in adults with either chronic obstructive pulmonary disease (COPD) or asthma. For more information about what these drugs do, see the How Trelegy Ellipta works section below. Instead, youll use a rescue inhaler for sudden trouble breathing. These include: Note: For more information about the potential negative effects of Trelegy Ellipta, see the Trelegy Ellipta side effects section above. Because of these actions, they work together to decrease COPD or asthma symptoms and make it easier for patients to breathe. These medications can be used for many different types of infections, such as bacterial, viral, or fungal. Trelegy Ellipta interacts with about 500 medications, and most of these interactions are moderate in severity, but may still have an important clinical impact. * This strength of Trelegy Ellipta is abbreviated as 100/62.5/25 mcg. The following information is provided for clinicians and other healthcare professionals. It takes rough 5.5 half-lives for the body to clear most, if not all, of a substance. It is approved by the FDA for three uses: for the long-term maintenance of chronic obstructive pulmonary disease (COPD); for the daily maintenance treatment of airflow obstruction in patients with COPD; and for the maintenance treatment of asthma in adults. The drug should not be used to treat acute bronchospasm associated with either COPD or asthma. There arent any foods that have been specifically reported to interact with Trelegy Ellipta. Trelegy Ellipta combines three medicines to improve lung function: fluticasone, a corticosteroid; vilanterol, a long-acting beta-agonist (LABA); and umeclidinium, an anticholinergic. How long does Sildenafil stay in your system? (This is a measurement of lung function and shows how much air you can breathe out in 1 second.) We comply with the HONcode standard for trustworthy health information. Trelegy Ellipta fluticasone furoate 100 mcg / umeclidinium 62.5 mcg / vilanterol 25 mcg inhalation powder (medicine). Drink eight to 10 glasses of water or fluids every day to help prevent dehydration, which can make side effects worse. However, its possible for the long-term use of inhaled steroids to cause weight gain. The combination of fluticasone and vilanterol has been studied as well. 2004-2023 Healthline Media UK Ltd, Brighton, UK, a Red Ventures Company. If you want to find the best Part D plan for you that includes Trelegy, call one of our Licensed Medicare experts at 1-888-376-2028. Trelegy Ellipta shouldnt be used later in pregnancy (at or after 28 weeks) or during labor unless recommended by your doctor. Trelegy Ellipta has been evaluated in the treatment of asthma or COPD in studies ranging from 12- to 52-weeks long. Trelegy Ellipta comes as an inhaler. No, you should never use Trelegy Ellipta as a rescue inhaler. There are currently no generic forms of either drug. Specifically, its important to avoid taking monoamine oxidase inhibitors (MAOIs) or tricyclic antidepressants while youre using Trelegy Ellipta. This mild side effect is explained in more detail below in Side effect details.. The drug vilanterol may relax the uterus, which can prevent contractions and cause problems during labor and delivery. Trelegy Ellipta contains three active drug ingredients: fluticasone, umeclidinium, and vilanterol. There arent any herbs or supplements that have been specifically reported to interact with Trelegy Ellipta. Trelegy Ellipta and Breo Ellipta are both brand-name drugs. Benzodiazepines and MDMA generally flag a urine test for up to 4 days after last dose. Trelegy Ellipta doesnt interact with alcohol. For information about this, see the Trelegy Ellipta use with other drugs section below. A long-term study of Trelegy Ellipta looked at side effects of the medication over the course of 52 weeks. Trelegy is used once daily in adults with either asthma or COPD to help breathing symptoms and reduce the number of flare-ups by lowering the swelling in your lungs and relaxing your airways. It is used once daily to help breathing symptoms and reduce the number of asthma or COPD flare-ups over the long-term. Can you take Trelegy and Symbicort together? There is insufficient data on the use of Trelegy Ellipta during pregnancy. After an intravenous dose, 58% is excreted in the feces and 22% is excreted in the urine. Bronchodilation is important in the treatment of COPD or asthma, as it helps to let more air into the lungs and allows for easier breathing. Trelegy Ellipta has a half-life of between 11 and 24 hours, so it will stay in your bloodstream for up to 5 days after your last dose. If you drink alcohol, talk with your doctor whether its safe for you to continue drinking while youre taking Trelegy Ellipta. Pulmonologist just switched me to Trelegy. Only second day but extremely short of breath. This medication is taken as one inhalation (puff) of Trelegy Ellipta once each day. Its not approved for use in children. The actual price youll pay depends on your insurance plan, your location, and the pharmacy you use. lower back or side pain. To help make sure that you dont miss a dose, try setting a reminder on your phone. Only open the tray when youre ready to start using the inhaler so you can use all of the doses before the inhaler expires. In clinical trials, Trelegy Ellipta was effective in treating asthma. If theyre more severe or dont go away, talk with your doctor or pharmacist. In September 2017, the FDA approved Trelegy Ellipta for the long-term maintenance of chronic obstructive pulmonary disease (COPD). Examples of examples of drugs that contain an anticholinergic medication include: If youre taking an anticholinergic drug, tell your doctor before you start using Trelegy Ellipta. Your doctor will determine the best dosage to fit your needs. Mild side effects* of Trelegy Ellipta can include: Most of these side effects may go away within a few days or a couple of weeks. Trelegy Ellipta is a combination medication that contains three drugs: fluticasone, umeclidinium, and vilanterol. Instead, youll use a rescue inhaler for sudden trouble breathing. In COPD patients: Upper respiratory tract infection, a runny nose and sore throat, pneumonia, taste disturbances, bronchitis, constipation, thrush (yeast infection) in your mouth and throat, painful and frequent urination (signs of a urinary tract infection), headache, nausea, vomiting, and diarrhea, back pain, mouth and throat pain, joint pain, cough, flu, hoarseness, and inflammation of the sinuses. That means with a half-life of 5 days, it will likely take 27.5 days-almost a whole month-for the body to clear this drug. For information about this, see the Trelegy Ellipta use with other drugs section below. ICS medicines work by decreasing lung inflammation (swelling) that can cause breathing problems. LAMA and LABA medicines are anticholinergic drugs that help to relax the muscles around the airways in the lungs. It is not used as a fast-acting rescue inhaler for sudden breathing problems. There are a total of 30 doses in each Trelegy Ellipta inhaler. The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. Store Trelegy Ellipta at room temperature between 68F to 77F (20C to 25C), away from heat and sunlight. This can eventually cause vision loss if its not treated. Oral thrush is a possible side effect of taking an inhaled steroid medication. However, in rats it is believed that pro-inflammatory transcription factors are inhibited along with antigen-induced lung eosinophilia. Vilanterol is also minimally absorbed orally. However, this doesnt mean that Trelegy Ellipta will be present in human breast milk. urinary tract infection *. Trelegy Ellipta Information for Consumers, Trelegy Ellipta Information for Healthcare Professionals. For more information about Trelegy Elliptas approved uses, see the Trelegy Ellipta for COPD and Trelegy Ellipta for asthma sections below. These medications each have their own time to maximum concentration (Cmax), time to steady state, metabolism, half-life, and elimination route. Some drugs can prolong (lengthen) a part of your heart rhythm called the QT interval. Examples of rescue inhalers include albuterol (Ventolin HFA, ProAir) and levalbuterol (Xopenex). As with all medications, the cost of Trelegy Ellipta can vary. changes in voice quality, such as hoarseness. Even if you dont taste or feel your dose, dont take another dose. Before you start treatment, tell your doctor if you have: heart or liver problems, high blood pressure, diabetes, seizures or epilepsy, thyroid problems, osteoporosis (weak or brittle bones), an immune system problem, or glaucoma (including increased pressure in your eye, cataracts, blurred vision, or other changes in vision). A certain type of diuretic called a non-potassium sparing diuretic can cause a decrease in your potassium level.

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